500 Error time to time

Site is usually working properly. However, sometimes I be getting 500 Error.

Here is my error log;

2022/04/22 09:07:01 [error] 5472#5472: *134035 upstream prematurely closed connection while reading response header from upstream, client: IPADDRESS, server: Link, request: "GET /login HTTP/2.0", upstream: "IpLink/login", host: "Link", referrer: "Link/"

2022/04/22 09:23:01 [error] 5472#5472: *134276 upstream prematurely closed connection while reading response header from upstream, client: IPADDRESS, server: Link, request: "POST /pay/response HTTP/2.0", upstream: "IpLink/pay/response", host: "Link"

2022/04/22 09:28:01 [error] 5472#5472: *134296 upstream prematurely closed connection while reading response header from upstream, client: IPADDRESS, server: Link, request: "GET /report/0f4f9d12-e39c-4608-912e-bb8e424cc556 HTTP/2.0", upstream: "IpLink/report/0f4f9d12-e39c-4608-912e-bb8e424cc556", host: "Link", referrer: "Link/dashboard"

2022/04/22 09:31:01 [error] 5472#5472: *134350 connect() failed (111: Connection refused) while connecting to upstream, client: IPADDRESS, server: Link, request: "GET /js/vendor.bundle.js.map HTTP/2.0", upstream: "IpLink/js/vendor.bundle.js.map", host: "Link"

2022/04/22 09:31:01 [error] 5472#5472: *134350 connect() failed (111: Connection refused) while connecting to upstream, client: IPADDRESS, server: Link, request: "GET /css/index.bundle.css.map HTTP/2.0", upstream: "IpLink/css/index.bundle.css.map", host: "Link"

2022/04/22 13:20:01 [error] 5472#5472: *134605 connect() failed (111: Connection refused) while connecting to upstream, client: IPADDRESS, server: Link, request: "GET / HTTP/1.1", upstream: "siteLinkWithIPAddress host: "Link"

2022/04/22 15:28:01 [error] 5472#5472: *134823 upstream prematurely closed connection while reading response header from upstream, client: IPADDRESS, server: Link, request: "GET / HTTP/2.0", upstream: "siteLinkWithIPAddress host: "Link", referrer: "Link/admin/form"
[Fri Jan 14 12:16:08.693152 2022] [autoindex:error] [pid 3807] [client IPADDRESS:39392] AH01276: Cannot serve directory /home/accio/web/siteName/public_html/: No matching DirectoryIndex (index.html,index.cgi,index.pl,index.php,index.xhtml,index.htm) found, and server-generated directory index forbidden by Options directive
[Fri Jan 14 12:16:41.687413 2022] [autoindex:error] [pid 3808] [client IPADDRESS:43734] AH01276: Cannot serve directory /home/accio/web/siteName/public_html/: No matching DirectoryIndex (index.html,index.cgi,index.pl,index.php,index.xhtml,index.htm) found, and server-generated directory index forbidden by Options directive
[Fri Jan 14 12:22:18.813455 2022] [autoindex:error] [pid 3810] [client IPADDRESS:59360] AH01276: Cannot serve directory /home/accio/web/siteName/public_html/: No matching DirectoryIndex (index.html,index.cgi,index.pl,index.php,index.xhtml,index.htm) found, and server-generated directory index forbidden by Options directive
[Fri Jan 14 12:22:20.697385 2022] [autoindex:error] [pid 3813] [client IPADDRESS:59430] AH01276: Cannot serve directory /home/accio/web/siteName/public_html/: No matching DirectoryIndex (index.html,index.cgi,index.pl,index.php,index.xhtml,index.htm) found, and server-generated directory index forbidden by Options directive