After update ip changed in exim4 settings and outgoing mail stays in spool

For part of domains (about 40%) file /etc/exim4/domains/
changed and out ip in this file changed for local ip from another iface.
That made outgoing mail stay on spool because of error connection with receivers smtp servers.
Are there any settings for that?
Is it /user/local/hestina/data/ips?
Should i leave here only 1 external ip?