No, Hestia doesn’t support that feature. You can suspend the mail account so that account won’t be able to logon but mails for that account will be accepted.
Yes, it is possible but not using Hestia Control Panel, you must modify exim4 conf and add the accounts manually to a file.
You can create a file like /etc/exim4/reject_rcpts and include there the mail address you want to reject, like [email protected] (one email address per line).
Then edit exim4 conf file /etc/exim4/exim4.conf.template and add this to acl_check_rcpt section:
Note: you can change the message but Unrouteable address is the text that Exim shows when the recipient address is not available.