As root:
systemctl edit nginx.service
This will open the file /etc/systemd/system/nginx.service.d/override.conf so you need to add two lines between the comments, as shown below:
### Editing /etc/systemd/system/nginx.service.d/override.conf
### Anything between here and the comment below will become the new contents of the file
[Service]
LimitNOFILE=250000
### Lines below this comment will be discarded
### /etc/systemd/system/nginx.service
Save the file and restart nginx
systemctl restart nginx.service
Check again the limits and also nginx:
cat /proc/$(cat /var/run/nginx.pid)/limits | grep -i 'Max open files'
nginx -t