I made changes to .css but it does not take effect?

I don’t use Apache but you could use something like this:

Note 1: In these examples we are removing caching, only for these extensions; htm, html, css, js (you can modify them to suit your needs).

Note 2: The extensions added, in this example; htm, html, css, js MUST be removed from the Proxy Extensions field:

newtemplate.tpl

server {
        listen      %ip%:%proxy_port%;
        server_name %domain_idn% %alias_idn%;
        error_log   /var/log/%web_system%/domains/%domain%.error.log error;

        include %home%/%user%/conf/web/%domain%/nginx.forcessl.conf*;

        location ~ /\.(?!well-known\/|file) {
                deny all;
                return 404;
        }

        location ~* \.(htm|html|css|js)$ {
                root       %docroot%;
                access_log /var/log/%web_system%/domains/%domain%.log combined;
                access_log /var/log/%web_system%/domains/%domain%.bytes bytes;
                open_file_cache off;
                proxy_cache off;
                proxy_no_cache 1;
                proxy_cache_bypass 1;
                add_header Cache-Control "no-store, no-cache, must-revalidate, proxy-revalidate, max-age=0";
                expires off;
                add_header Pragma "no-cache";
                etag off;
                fastcgi_hide_header "Set-Cookie";
        }

        location / {
                proxy_pass http://%ip%:%web_port%;

                location ~* ^.+\.(%proxy_extensions%)$ {
                        try_files  $uri @fallback;

                        root       %docroot%;
                        access_log /var/log/%web_system%/domains/%domain%.log combined;
                        access_log /var/log/%web_system%/domains/%domain%.bytes bytes;

                        expires    max;
                }
        }

        location @fallback {
                proxy_pass http://%ip%:%web_port%;
        }

        location /error/ {
                alias %home%/%user%/web/%domain%/document_errors/;
        }

        include %home%/%user%/conf/web/%domain%/nginx.conf_*;
}

newtemplate.stpl

server {
        listen      %ip%:%proxy_ssl_port% ssl;
        server_name %domain_idn% %alias_idn%;
        error_log   /var/log/%web_system%/domains/%domain%.error.log error;

        ssl_certificate     %ssl_pem%;
        ssl_certificate_key %ssl_key%;
        #Commented out ssl_stapling directives due to Lets Encrypt ending OCSP support in 2025
        #ssl_stapling        on;
        #ssl_stapling_verify on;

        # TLS 1.3 0-RTT anti-replay
        if ($anti_replay = 307) { return 307 https://$host$request_uri; }
        if ($anti_replay = 425) { return 425; }

        include %home%/%user%/conf/web/%domain%/nginx.hsts.conf*;

        location ~ /\.(?!well-known\/|file) {
                deny all;
                return 404;
        }

        location ~* \.(htm|html|css|js)$ {
                root       %docroot%;
                access_log /var/log/%web_system%/domains/%domain%.log combined;
                access_log /var/log/%web_system%/domains/%domain%.bytes bytes;
                open_file_cache off;
                proxy_cache off;
                proxy_no_cache 1;
                proxy_cache_bypass 1;
                add_header Cache-Control "no-store, no-cache, must-revalidate, proxy-revalidate, max-age=0";
                expires off;
                add_header Pragma "no-cache";
                etag off;
                fastcgi_hide_header "Set-Cookie";
        }

        location / {
                proxy_pass https://%ip%:%web_ssl_port%;

                location ~* ^.+\.(%proxy_extensions%)$ {
                        try_files  $uri @fallback;

                        root       %sdocroot%;
                        access_log /var/log/%web_system%/domains/%domain%.log combined;
                        access_log /var/log/%web_system%/domains/%domain%.bytes bytes;

                        expires    max;
                }
        }

        location @fallback {
                proxy_pass https://%ip%:%web_ssl_port%;
        }

        location /error/ {
                alias %home%/%user%/web/%domain%/document_errors/;
        }

        proxy_hide_header Upgrade;

        include %home%/%user%/conf/web/%domain%/nginx.ssl.conf_*;
}